Muscadine Plus MPX. Prostate & PSA Research Links.


Men with prostate and PSA issues are interested in studies using Muscadine Plus MPX muscadine seed.


This blog post contains links to four articles which discuss the efficacy of Muscadine Plus MPX for prostate treatment.


The Muscadinex MX1 supplement (details at the end of this post) includes 325mg of the Muscadine Plus MPX powder used in the research. The powder is sourced from Muscadine Naturals of North Carolina, who hold a patent for processing muscadine grapes.


Disclaimer.


Please note that these research links are for consumer research purposes only. They are not an endorsement or recommendation by Muscadinex, and are not meant to replace advice from a physician.


Consumer protection. To read more about FDA oversight for herbal supplements, please visit:

https://www.fda.gov/food/information-consumers-using-dietary-supplements/questions-and-answers-dietary-supplements


Research link #1

Muscadine Grape Skin Extract (MPX) in Men with Biochemically Recurrent Prostate (condition): A Randomized, Multicenter, Placebo-Controlled Clinical Trial.


Synopsis. "MPX (Muscadine Plus), a commercial preparation of powdered

muscadine grape skin, distributed as a dietary supplement, contains ellagic acid and its precursors, the flavonoids quercetin and epicatechin, and the stillbenoid trans-resveratrol, which have demonstrated (beneficial) activity in prostate (condition) cells in vitro.


Invasive DU145 cells treated with quercetin displayed delayed migration, depressed invasion, and inhibited capillary formation."


https://clincancerres.aacrjournals.org/content/clincanres/early/2017/12/14/1078-0432.CCR-17-1100.full.pdf

Research link #2

Effects of Two Doses of MPX Capsules on Rising Prostate-specific Antigen Levels in Men Following Initial Therapy for Prostate (condition).


Synopsis. "This research is being done to test an investigational product called Muscadine Plus in the treatment of men who have received initial therapy (surgery and or radiation, cryotherapy or brachytherapy) for prostate (condition) and are experiencing a rise in their prostate-specific antigens (PSA) level."


https://clinicaltrials.gov/ct2/show/NCT01317199

Research link #3

Muscadine Plus in Treating Rising PSA Levels in Men Carrying a Specific Gene Variant (Alanine / Alanine SOD2 Genotype) Following Initial Therapy for Prostate (condition).


Synopsis. "Each treatment cycle consists of once daily oral dosing of 4000 mg Muscadine Plus, every day throughout each 12 week (84 day) cycle. Patients may continue to receive additional cycles of study drug and will be followed every three months with standard visits with their physician until completion of 48 weeks of study treatment, disease progression, or until they wish to discontinue the drug.


Ellagic acid inhibits DNA Methyltransferase. DNA Methyltransferases (DNMTs) are a family of enzymes that regulate chromatin methylation and use S-adenosyl methionine (SAM) as the methyl donor. Ellagic acid's metabolite, urolithin-A inhibits the protein complex nuclear factor kappa-light-enhancer of activated B-cells (NFkB), potentially leading to increased rates of apoptosis and decreases in cell proliferation. Extracts from Vitis rotundifolia have shown inhibition of the phosphatidylinositol 3-kinase-Akt pathway."


https://www.smartpatients.com/trials/NCT03535675

Research link #4

Muscadine Plus in Treating Rising PSA Levels in Men Carrying a Specific Gene Variant (Alanine / Alanine SOD2 Genotype) Following Initial Therapy for Prostate (condition).


Synopsis. "Muscadine plus (MPX) is made from Muscadine grape skins that have been dried and ground into powder. Studies in the laboratory suggest the grape skins contain natural compounds that slow the growth of prostate (condition). About one out of every four men has the specific deoxyribonucleic acid (DNA) (Alanine / Alanine SOD2 Genotype) that might make them more responsive to MPX. Prostate specific antigen (PSA) is a protein produced by the cells of the prostate gland. PSA test can monitor patients with a history of prostate (condition) to see if the (condition) has come back. This phase III trial studies how well MPX works in treating rising prostate-specific antigen levels (PSA) in men, following initial therapy for prostate (condition) compared to those not taking MPX."


https://www.cancer.gov/about-cancer/treatment/clinical-trials/search/v?id=NCI-2018-02957&r=1

About Muscadine Plus MX1 muscadine extract supplement and prostate health.


Per vegetarian capsule:

325mg MPX Muscadine Plus muscadine skin powder

325mg Muscadine seed powder

5mg BioPerine ®


✅ IMMUNE BOOST + CELLULAR HEALTH. Muscadines are up to 100x stronger than European grapes. We provide a natural immunity and longevity polyphenol / proanthocyanidin blend of resveratrol, quercetin, ellagic acid and grapeseed OPC antioxidants. 325mg Muscadine Plus MPX skin (polyphenols) AND 325mg muscadine seed (OPC antioxidants) per capsule.


✅ NATURAL 1544% BOOST. 5mg BioPerine piperine black pepper extract boosts resveratrol Cmax blood serum up to 1544% and polyphenol bio-availability up to 229%. Enhances cardio, immune system and longevity benefits.


✅ NO ADDITIVES. NO fillers, NO artificial ingredients, NO GMO, No gluten. NO Japanese knotweed. NO laboratory resveratrol. Just 100% vegetarian / vegan quality. Vegetarian capsules. Paleo & Keto compatible.


✅ MADE IN THE USA QUALITY. Independently tested. Certified cGMP manufacturing quality standards. FDA-inspected facilities. 100% USA muscadines. NO imported fruit. Homeland health you can trust.


✅ AGE BETTER. Our holistic, natural blend of muscadine skin and muscadine seed is popular with people who want to age better and extend their golden years. Simply return your product to Amazon if you are not completely satisfied. We have made quality supplements since 2013.


This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.


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