Resveratrol : Alzheimer’s Dementia Research reports.


couple contemplate effects of alzheimer's

Have you ever woken up in a hotel bedroom and wondered where you were? Do you remember those horrible few seconds of feeling unsafe and confused?


Now imagine what it’s like to feel like that for an hour, then a day, then for weeks at a time. Then forever.


That’s what the onset of Alzheimer’s must feel like. And for one in three of us, it’s an illness just waiting to happen. In fact, according to the Alzheimer’s Association (see below) another American develops Alzheimer’s syndrome every 65 seconds.


"The number of Americans living with Alzheimer's is growing — and growing fast. An estimated 5.8 million Americans of all ages have Alzheimer's.


An estimated 5.8 million Americans of all ages are living with Alzheimer's dementia in 2019. This number includes an estimated 5.6 million people age 65 and older and approximately 200,000 individuals under age 65 who have younger-onset Alzheimer's."


https://www.alz.org/alzheimers-dementia/facts-figures



Here’s some Alzheimer's Association figures:

  • 6th leading cause of death in the U.S.

  • 5.8m Americans living with Alzheimer's.

  • Every 65 seconds in the U.S., someone develops Alzheimer's.

  • It's a growing problem. Between 2000 and 2017 heart disease deaths went down by 9%, but Alzheimer's went up by 145%.

  • 82% of seniors say it's important to be checked.

  • 1 in 3 seniors die with Alzheimer's or dementia.


Muscadine grape resveratrol. Part of a natural defense against cognitive decline?


You might have read that Alzheimer’s is the result of amyloid plaque building up in the brain. It’s a process that can start many years before the symptoms of Alzheimer’s and dementia become apparent.


Other studies suggest that there’s a strong link between diabetes and Alzheimer’s. In fact some researchers refer to Alzheimer’s as Type 3 diabetes.


With such high rates of people being affected by Alzheimer’s, many prudent Americans start to think about the risk factors of aging once they reach middle age. People want to know how they can develop a strategy that helps protects them against mental decline, and also offers some protection against diabetes, cardio problems and other diseases of aging.


Macro factors are developing a healthier lifestyle. You know the drill: more exercise, watch your weight, consume quality foods, cut down on sugar and avoid tobacco. These big steps will be the foundation of a lifestyle that increase your chances of aging healthily.


Micro factors include the miniscule molecules which affect your cells, your DNA, and how your body protects itself at a microscopic level. And in the context of Alzheimer’s protection, an important molecule researchers have identified is resveratrol, as found in muscadine grape skins.


The muscadine is America’s strongest source of grape resveratrol. Resveratrol is a polyphenol, antioxidant molecule. Muscadine skin also includes the polyphenols ellagic acid, quercetin, myricetin and kaempferol.


Resveratrol is sometimes referred to as the ‘red wine miracle’. Hundreds of research studies link it to a wide range of antiaging health benefits.


Here’s two medical research studies that might help you plan your ‘golden years strategy’:


Research #1

Neuroprotective Mechanisms of Resveratrol in Alzheimer’s Disease: Role of SIRT1.


Extract. "Alzheimer’s disease (AD) is a progressive and neurodegenerative disorder of the cortex and hippocampus, which eventually leads to cognitive impairment. Although the etiology of AD remains unclear, the presence of β-amyloid (Aβ) peptides in these learning and memory regions is a hallmark of AD. Therefore, the inhibition of Aβ peptide aggregation has been considered the primary therapeutic strategy for AD treatment. Many studies have shown that resveratrol has antioxidant, anti-inflammatory, and neuroprotective properties and can decrease the toxicity and aggregation of Aβ peptides in the hippocampus of AD patients, promote neurogenesis, and prevent hippocampal damage."


https://www.hindawi.com/journals/omcl/2018/8152373/


Research #2

Resveratrol for Alzheimer’s disease.


Extract. "The amyloid hypothesis suggests that the progressive accumulation and deposition of central nervous system amyloid with aging is the proximate cause of Alzheimer’s disease (AD). Thus, targeting molecular mechanisms of aging may represent a viable treatment approach. Caloric restriction prevents diseases of aging, including AD, in animal models, perhaps by activation of sirtuins. The sirtuins (such as mammalian SIRT1) are deacetylases that link energy balance (NAD+/NADH) to regulation of gene transcription. Resveratrol is a potent activator of SIRT1, and thus may mimic caloric restriction to prevent diseases of aging."


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664214/


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